Siddha - A Traditional Precision Medicine

1. Siddha personalized medicine can be effectively bridged with modern precision medicine by integrating traditional diagnostic methods such as Envagai Thervu, Naadi, Neerkuri, Neikuri, individual constitution (Yakkai), diet, lifestyle, and environmental factors with modern technologies including genomics, multi-omics, biomarkers, artificial intelligence, machine learning, digital health records, imaging, and wearable devices. 

2. This integration can scientifically validate and standardize Siddha diagnostics, enable AI-assisted clinical decision-making, support biomarker-based personalized therapies, and generate robust clinical evidence. 

3. The result is an evidence-based Siddha Precision Medicine model that combines ancient wisdom with modern science to deliver predictive, preventive, personalized, and participatory healthcare.

Seeraga choornam & Acid Peptic Disease

 SIDDHA: An Evidence-Based Medical System

Seeraga choornam & Acid Peptic Disease

Acid peptic disease (APD) comprises a group of disorders resulting from excessive gastric acid secretion or impaired mucosal defence of the stomach and duodenum. It includes gastritis, gastric ulcer, duodenal ulcer, and gastroesophageal reflux disease (GERD).

In the Siddha system of medicine, APD is broadly correlated with Gunmam, in which Vatham is considered to play a pivotal role in its pathogenesis, as reflected in the classical dictum: "Thodar Vatha Bandhamalathu Gunmam Varathu" (Gunmam does not manifest without the involvement of Vatham).

In this preliminary or pilot study, the authors evaluated the clinical effectiveness of Seeraga Choornam in 25 patients with acid peptic disease. All patients received the formulation for 48 days and experienced symptomatic relief, with the average time to symptom resolution being approximately 20 days. The authors attributed the therapeutic efficacy of Seeraga Choornam to its sweet taste (Inippu Suvai), which is believed to pacify aggravated Vatham, thereby alleviating the manifestations of Gunmam.

For more details view the article: https://www.academia.edu/.../Clinical_trial_of_Seeraga...

Note: Medicine should be taken only under the consultation and prescription of a qualified Siddha physician.

ANTIOXIDANT EFFECT OF MADHUMEGA CHOORANAM

 Siddha Medicine: An Evidence-Based Medical System

ANTIOXIDANT EFFECT OF MADHUMEGA CHOORANAM

In Diabetes Mellitus, persistent hyperglycemia leads to excessive production of oxygen free radicals, also known as Reactive Oxygen Species (ROS), through the autooxidation of glucose and the glycosylation of proteins. This process ultimately results in oxidative stress, which plays a significant role in the development of vascular complications. These vascular complications are the primary contributors to various forms of diabetic complications.

To prevent these adverse effects, the endogenous (natural) antioxidant defence system of the body comprising enzymatic antioxidants such as superoxide dismutase and glutathione peroxidase, as well as non-enzymatic antioxidants like ascorbic acid, flavonoids, and phenolic compounds etc., needs to be enhanced or supplemented with proven natural antioxidants from herbal sources.

Madhumega Choornam, a well-known anti-diabetic Siddha polyherbal formulation, was evaluated by the investigators for its in vitro antioxidant activity, along with its phenolic content, to assess its free radical scavenging potential. Various in vitro assays, including DPPH radical scavenging activity, reducing power assay, total antioxidant activity, and superoxide radical scavenging activity, were performed and compared with the standard, ascorbic acid by the investigators in this study. The findings of this study validate the use of Madhumega Choornam as a potential antioxidant in the management of diabetes.

Click the link: https://wjpr.s3.ap-south-1.amazonaws.com/.../1540986821.pdf

Note: Medicines should be taken only under the consultation and prescription of a qualified Siddha physician.

ANTI-HYPERTENSIVE EFFECT OF VENTHAMARAI CHOORNAM

 Siddha Medicine: An Evidence-Based Medical System

ANTI-HYPERTENSIVE EFFECT OF VENTHAMARAI CHOORNAM

Venthamarai chooranam, a poly-herbal Siddha medicine, composed of Nelumbo nucifera, Elaettaria cardamomum, Zingiber officinale, Piper longum, Glycyrrhiza glabra, Anethum graveolens and Cuminum cyminum used for the treatment of hypertension by Siddha physicians.

An experimental study was conducted by a team of researchers to elucidate the antihypertensive mechanism of Venthamarai Choornam in an animal model of renovascular hypertension. The study evaluated the effect of Venthamarai Choornam on the renin–angiotensin system, endothelial function, inflammation, and oxidative stress associated with hypertension.

Angiotensin II mainly acts through angiotensin type-1 (AT1) receptors, whose excessive activation is linked to high blood pressure, inflammation, and oxidative stress. In contrast, angiotensin type-2 (AT2) receptors exert protective and blood pressure-lowering effects. The investigators found that Venthamarai Choornam reduced the overexpression of AT1 receptors while increasing AT2 receptor expression, thereby enhancing nitric oxide production. The formulation also increased endothelial nitric oxide synthetase (eNOS) expression, leading to improved plasma nitric oxide levels and reduction in systolic blood pressure in hypertensive rats. In addition, the formulation significantly reduced pro-inflammatory cytokines and oxidative stress markers involved in vascular damage and hypertensive complications.

The findings suggest that Venthamarai Choornam exerts antihypertensive effects by regulating the renin–angiotensin system, improving endothelial function, and reducing inflammation and oxidative stress. The investigators further opined that the substantial presence of flavonoids, particularly quercetin, may partly contribute to the observed antihypertensive effects.

Click the link: https://pubmed.ncbi.nlm.nih.gov/24719376/

Note: Medicine should be taken only under the consultation and prescription of a qualified Siddha physician.

Possible mechanisms of Siddha Anti-Cancer Medicines

 SIDDHA: An Evidence-Based Medical System

Possible mechanisms of Siddha Anti-Cancer Medicines

Thiripala Choornam has demonstrated significant cytotoxic and antiproliferative activity against various cancer cell lines, including cervical adenocarcinoma, endometrial adenocarcinoma, breast adenocarcinoma, oral squamous cell carcinoma, lung carcinoma, hepatocellular carcinoma, prostate cancer, ovarian cancer, and pancreatic cancer. Beyond its cytotoxic effects, mechanistic studies have shown that it can induce apoptosis, regulate cell-cycle arrest, modulate mitochondrial pathways, alter Bax/Bcl-2 expression ratios, activate caspases, and suppress invasive and metastatic behaviour of cancer cells.

2. Rasam related formulations may induce intracellular oxidative stress, leading to mitochondrial dysfunction and activation of the intrinsic apoptotic pathway. This process involves the release and enhancement of cytochrome-c from mitochondria, which subsequently activates the caspase pathway. Caspases, the intracellular enzymes responsible for apoptosis, promote DNA damage and ultimately lead cancer cells to undergo programmed cell death.

3. Thamiram based formulations may elevate intracellular copper levels, thereby disrupting cancer cell homeostasis and promoting excessive generation of reactive oxygen species (ROS). The resulting sustained redox imbalance can induce mitochondrial dysfunction, lipid peroxidation, and DNA damage, ultimately inhibiting tumour cell proliferation and promoting cancer cell death.

Click the link: https://pmc.ncbi.nlm.nih.gov/articles/PMC13177046/

Note: Medicine should be taken only under the consultation and prescription of a qualified Siddha physician.